Cell adhesion in vascular biology: series introductin.
نویسندگان
چکیده
منابع مشابه
Perspectives Series: Cell Adhesion in Vascular Biology
The adhesive properties of the endothelium, the single-cellthick lining of the cardiovascular system, are central to its biology and pathobiology. In health, the luminal endothelial surface provides a relatively nonadhesive, nonthrombogenic container for the cellular and macromolecular constituents of the blood. Specialized adhesive molecules localized at the lateral cell–cell junctions control...
متن کاملPerspectives Series: Cell Adhesion in Vascular Biology
Previous articles in this series have emphasized the fundamental importance of adhesion receptors in vascular biology. One class of these receptors, the integrins, is necessary for vascular and hematopoietic cell development, angiogenesis, cell migration in response to injury, and extracellular matrix assembly. Furthermore, an integrin specific to platelets and megakaryocytes, a IIb b 3 , is in...
متن کاملPerspectives Series: Cell Adhesion in Vascular Biology
Leukocytes and the trafficking processes that direct these cells to their tissue sites of function, represent mainstays in the mammalian armamentarium against microbial pathogens. Trafficking processes are equally relevant to recruitment of immune cells which engage in functions that include localized immune response and tissue remodeling activities. The remarkable vigor with which leukocytes s...
متن کاملPerspectives Series: Cell Adhesion in Vascular Biology
Cell adhesion plays a key role in a number of diverse biological processes, including inflammation and thrombosis. In the cardiovascular system, cells are exposed constantly to hemodynamic forces due to the flow of blood. Cell attachment to vessel wall depends on the balance between the dispersive hydrodynamic forces and the adhesive forces generated by the interaction of membrane-bound recepto...
متن کاملPerspectives Series: Cell Adhesion in Vascular Biology
Integrins, a family of heterodimeric membrane proteins, serve in one of their main roles as adhesion receptors for various extracellular matrix components (1, 2). The integrin–matrix interaction is a two-way street. Most extracellular matrix proteins are ligands for integrins, allowing integrins to mediate cell attachment, and the matrix may, at least to a degree, control the expression and act...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1996
ISSN: 0021-9738
DOI: 10.1172/jci118939